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GSK2334470

GSK2334470

Item no.	V0237-250mg
Manufacturer	InvivoChem LLC
CASRN	1227911-45-6
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0237CAS #:1227911-45-6Purity >=98% Description: GSK2334470 (GSK-2334470) is a novel, highly specific and potent inhibitor of PDK1 (3-phosphoinositide-dependent protein kinase) with potential antitumor activity.It inhibits PDK-1 with an IC50 of ca.10 nM in a cell-free assay, and showed no effects on close related AGC-kinases. GSK2334470 exhibited potent antiproliferative activity in vitro and high antitumor efficacy in vivo by preventing PDK1 from activating full-length Akt1or mutant Akt1 lacking the PH domain. Description: Description: GSK2334470 (GSK-2334470) is a novel, highly specific and potent inhibitor of PDK1 (3-phosphoinositide-dependent protein kinase) with potential antitumor activity.It inhibits PDK-1 with an IC50 of ca.10 nM in a cell-free assay, and showed no effects on close related AGC-kinases. GSK2334470 exhibited potent antiproliferative activity in vitro and high antitumor efficacy in vivo by preventing PDK1 from activating full-length Akt1or mutant Akt1 lacking the PH domain. GSK-2334470 References: Biochem J. 2011 Jan 15; 433(2):357-69; J Cell Sci. 2012 Jul 1; 125(Pt 13):3153-63; PLoS One. 2013; 8(3):e58703. References:References:

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Amount: 250 mg

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Delivery expected until 10/2/2025

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