XL019

Item no.	V0330-100mg
Manufacturer	InvivoChem LLC
CASRN	945755-56-6
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0330CAS #:945755-56-6Purity >=98% Description: XL019 is a novel, potent and selective and orally bioavailable inhibitor of Janus kinase-JAK2 with potential antitumor activity. It inhibits JAK2 with an IC50 of 2.2 nM, and exhibits > 50-fold selectivity for JAK2 over JAK1, JAK3 and TYK2. It shows potent in vitro antiproliferative activity and high in vivo antitumor efficacy. XL019 inhibits the activation of JAK2 as well as the mutated form JAK2V617F, which may result in the inhibition of the JAK-STAT signaling pathway and may induce apoptosis. The JAK2 mutated form JAK2V617F has a valine-to-phenylalanine modification at position 617 and plays a key role in tumor cell proliferation and survival. Description: References: Bioorg Med Chem Lett. 2012 Dec 15; 22(24):7653-8; Hematology Am Soc Hematol Educ Program. 2009:636-42. References:
Molecular Weight (MW)	444.53
Formula	C25H28N6O2
CAS No.	945755-56-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 16 mg/mL (36.0 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: (S)-N-(4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)phenyl)pyrrolidine-2-carboxamide InChi Key: ISOCDPQFIXDIMS-QHCPKHFHSA-N InChi Code: InChI=1S/C25H28N6O2/c32-24(23-2-1-12-26-23)28-19-5-3-18(4-6-19)22-11-13-27-25(30-22)29-20-7-9-21(10-8-20)31-14-16-33-17-15-31/h3-11, 13, 23, 26H, 1-2, 12, 14-17H2, (H, 28, 32)(H, 27, 29, 30)/t23-/m0/s1 SMILES Code: O=C([CH]1NCCC1)NC2=CC=C(C3=NC(NC4=CC=C(N5CCOCC5)C=C4)=NC=C3)C=C2
Synonyms	Synonym: XL-019; XL 019; XL019

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Amount: 100 mg

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