Comparison

S-Ruxolitinib (INCB-018424)

Item no. V0337-100mg
Manufacturer InvivoChem LLC
CASRN 941685-37-6
Amount 100 mg
Quantity options 10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Available
Description
InvivoChem Cat #:V0337CAS #:941685-37-6 (S-enantiomer) Purity >=98%

Description: S-Ruxolitinib, the S-enantiomer of ruxolitinib which is also known as INC424 and INCB18424 or INCB018424, is the first-in class, potent, selective, and orally bioavailable JAK1/2 (Janus-associated kinase) inhibitor with IC50 of 3.3 nM/2.8 nM in cell-free assays, it exhibits > 130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib has potential antineoplastic and immunomodulating activities. It was approved in 2011 by FDA for the treatment of intermediate or high-risk myelofibrosis, a type of myeloproliferative disorder that affects the bone marrow, and for polycythemia vera (PCV) when there has been an inadequate response to or intolerance of hydroxyurea. It selectively binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation.

Description:

References: Blood. 2010 Apr 15; 115(15):3109-17; N Engl J Med. 2012 Mar 1; 366(9):799-807.

References:

Related CAS: 941685-37-6; 941678-49-5 (free base); 1092939-16-6 (sulfate); 1092939-17-7 (phosphate)

Molecular Weight (MW)
306.37
Formula
C17H18N6
CAS No.
941685-37-6 (S-enantiomer);
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Solubility (In vitro)
DMSO: 61 mg/mL (199.1 mM)
Water: < 1 mg/mL
Ethanol: < 1 mg/mL
Solubility (In vivo)
0.5% CMC+0.25% Tween 80: 30 mg/mL
Synonyms

S Ruxolitinib; INCB-018424, INCB 018424, INCB018424; INC424, INC424, INC-424; INCB18424, INCB 18424, INCB-18424; Jakafi and Jakavi (trade name); (S)-INCB018424; S-Ruxolitinib; SRuxolitinib;

Chemical Name: (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile

InChi Key: HFNKQEVNSGCOJV-HNNXBMFYSA-N

InChi Code: InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6, 8-12, 15H, 1-5H2, (H, 19, 20, 21)/t15-/m0/s1

SMILES Code: N#CC[CH](C1CCCC1)N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 mg
Available: In stock
available

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