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Gandotinib (LY-2784544)

Gandotinib (LY-2784544)

Item no.	V0341-25mg
Manufacturer	InvivoChem LLC
CASRN	1229236-86-5
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 500 mg 50 mg 5 mg
Category	Cardiovascular Research Ischemia & Reperfusion Injury Myocardial Infarction Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0341CAS #:1229236-86-5Purity >=98% Description: Gandotinib (formerly also known as LY2784544) is a novel, potent and selective JAK2 (Janus kinase) inhibitor with potential antitumor activity. It inhibits JAK2 with an IC50 of 3 nM, and shows 8- and 20-fold selectivity for JAK2 over JAK1 and JAK3. It shows potent in vitro antiproliferative activity and high in vivo antitumor efficacy. Gandotinib effectively inhibited JAK2V617F-driven signaling and cell proliferation in Ba/F3 cells (IC50=20 and 55?nM, respectively). In vivo, Gandotinib effectively inhibited STAT5 phosphorylation in Ba/F3-JAK2V617F-GFP ascitic tumor cells and significantly reduced Ba/F3-JAK2V617F-GFP tumor burden in the JAK2V617F-induced MPN model. Description: References: Blood Cancer J. 2013 Apr 12; 3:e109. References
Molecular Weight (MW)	469.94
Formula	C23H25ClFN7O
CAS No.	1229236-86-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 94 mg/mL (200.0 mM)
	Water: < 1 mg/mL
	Ethanol: 9 mg/mL (19.1 mM)
Other info	Chemical Name: 3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(3-methyl-1H-pyrazol-5-yl)-8-(morpholinomethyl)imidazo[1, 2-b]pyridazin-6-amine InChi Key: SQSZANZGUXWJEA-UHFFFAOYSA-N InChi Code: InChI=1S/C23H25ClFN7O/c1-14-9-21(29-28-14)27-22-11-17(13-31-5-7-33-8-6-31)23-26-15(2)20(32(23)30-22)10-16-3-4-18(24)12-19(16)25/h3-4, 9, 11-12H, 5-8, 10, 13H2, 1-2H3, (H2, 27, 28, 29, 30) SMILES Code: CC1=NNC(NC2=NN3C(C(CN4CCOCC4)=C2)=NC(C)=C3CC5=CC=C(Cl)C=C5F)=C1
Synonyms	LY-2784544; Gandotinib; LY 2784544; LY2784544;

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Amount: 25 mg

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Delivery expected until 10/2/2025

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