ZM 447439

Description: ZM 447439 (ZM-447439) is a novel, potent, selective and ATP-competitive inhibitor of Aurora A and Aurora B with potential antitumor activity. It inhibits Aurora A and Aurora B with IC50s of 110 nM and 130 nM, respectively. It shows 8-fold higher selectivity for Aurora A/B over MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc. Being specifically for Aurora kinases, ZM 447439 barely inhibits the majority of other protein kinases (IC50 > 10 uM), such as CDK1/2/4, IKK1/2, PLK1, CHK1, cFLT2, KDR2, FAK and Zap-70, except for MEK1, SRC and LCK (IC50 values of 1.79 uM, 1.03 and 0.88 uM respectively.

References: Neuroendocrinology. 2010; 91(2):121-30; J Cell Biol. 2003 Apr 28; 161(2):267-80.

Synonym: ZM-447439; ZM 447439; ZM447439.

Chemical Name: N-(4-((6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)benzamide

InChi Key: OGNYUTNQZVRGMN-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4, 6-11, 18-20H, 5, 12-17H2, 1H3, (H, 33, 35)(H, 30, 31, 32)

SMILES Code: O=C(NC1=CC=C(NC2=C3C=C(OC)C(OCCCN4CCOCC4)=CC3=NC=N2)C=C1)C5=CC=CC=C5