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TCS7010 (Aurora A Inhibitor I)

TCS7010 (Aurora A Inhibitor I)

Item no.	V0358-50mg
Manufacturer	InvivoChem LLC
CASRN	1158838-45-9
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0358CAS #:1158838-45-9Purity >=98% Description: TCS 7010 (Aurora A Inhibitor I; TCS-7010 ) is a novel, potent, and highly selective inhibitor of Aurora A kinase-AAK with potential antitumor activity. It inhibits Aurora A kinase with an IC50 of 3.4 nM in a cell-free assay and shows 1000-fold higher selectivity for Aurora A over Aurora B. TCS7010 shows potent in vitro antiproliferative activity and high in vivo antitumor efficacy. Description: References: J Med Chem. 2009 May 28; 52(10):3300-7; Carcinogenesis. 2012 Feb; 33(2):285-93. References:
Molecular Weight (MW)	588.07
Formula	C31H31ClFN7O2
CAS No.	1158838-45-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 118 mg/mL (200.6 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide InChi Key: AKSIZPIFQAYJGF-UHFFFAOYSA-N InChi Code: InChI=1S/C31H31ClFN7O2/c1-2-39-15-17-40(18-16-39)28(41)19-21-7-11-24(12-8-21)36-31-34-20-26(33)29(38-31)35-23-13-9-22(10-14-23)30(42)37-27-6-4-3-5-25(27)32/h3-14, 20H, 2, 15-19H2, 1H3, (H, 37, 42)(H2, 34, 35, 36, 38) SMILES Code: O=C(NC1=CC=CC=C1Cl)C2=CC=C(NC3=NC(NC4=CC=C(CC(N5CCN(CC)CC5)=O)C=C4)=NC=C3F)C=C2
Synonyms	TC S 7010; TCS 7010; TC-S7010

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Amount: 50 mg

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Delivery expected until 9/4/2025

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