PHA-680632

Description: PHA-680632 (PHA680632) is a novel and potent pan-aurora kinase inhibitor with potential antitumor activity. It inhibits Aurora A/B/C with IC50s of 27 nM, 135 nM and 120 nM, respectively, and shows 10- to 200-fold higher selectivity for aurora over FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3. Moreover, PHA 680632 shows potent in vitro antiproliferative activity and high in vivo antitumor efficacy. It potently inhibits proliferation of various cancer cells including HCT116, A2780, HL60 and Hela cells with IC50 values in the nanomolar to micromolar range (0.06 to 7.15 uM).

References: Clin Cancer Res. 2006 Jul 1; 12(13):4080-9; Br J Cancer. 2007 Dec 17; 97(12):1664-72.

Synonym: PHA 680632; PHA-680632; PHA 680632.

Chemical Name: N-(2, 6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)pyrrolo[3, 4-c]pyrazole-5(1H, 4H, 6H)-carboxamide

InChi Key: OBWNXGOQPLDDPS-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H35N7O2/c1-4-19-7-6-8-20(5-2)25(19)29-28(37)35-17-23-24(18-35)31-32-26(23)30-27(36)21-9-11-22(12-10-21)34-15-13-33(3)14-16-34/h6-12H, 4-5, 13-18H2, 1-3H3, (H, 29, 37)(H2, 30, 31, 32, 36)

SMILES Code: O=C(N(C1)CC2=C1C(NC(C3=CC=C(N4CCN(C)CC4)C=C3)=O)=NN2)NC5=C(CC)C=CC=C5CC