GSK503

Item no.	V0387-100mg
Manufacturer	InvivoChem LLC
CASRN	1346572-63-1
Amount	100 mg
Quantity options	10 mg 250 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #: V0387CAS #:1346572-63-1Purity >=98% Description: GSK503 (GSK-503) is a novel, potent and specific inhibitor of Enhancer of zeste homolog 2 (EZH2) methyltransferase inhibitor with potential antitumor activity. It inhibits EZH2 with Kiapp of 3 to 27 nM. GSK503 demostrates excellent antiproliferative activity and high in vivo antitumor efficacy in a melanoma mouse model. Description: References: Cancer Cell. 2013 May 13; 23(5):677-92; Nat Commun. 2015 Jan 22; 6:6051. References:
Molecular Weight (MW)	526.67
Formula	C31H38N6O2
CAS No.	1346572-63-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (189.8 mM)
	Water: < 1 mg/mL
	Ethanol: 26 mg/mL warmed (49.4 mM)
SMILES	O=C(C1=CC(C2=CC=C(N3CCN(C)CC3)N=C2)=CC4=C1C(C)=CN4C(C)C)NCC5=C(C)C=C(C)NC5=O
Synonyms	GSK 503; GSK503; GSK-503 Chemical Name: N-((4, 6-dimethyl-2-oxo-1, 2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide InChi Key: HRDQQHUKUIKFHT-UHFFFAOYSA-N InChi Code: InChI=1S/C31H38N6O2/c1-19(2)37-18-21(4)29-25(30(38)33-17-26-20(3)13-22(5)34-31(26)39)14-24(15-27(29)37)23-7-8-28(32-16-23)36-11-9-35(6)10-12-36/h7-8, 13-16, 18-19H, 9-12, 17H2, 1-6H3, (H, 33, 38)(H, 34, 39) SMILES Code: O=C(C1=CC(C2=CC=C(N3CCN(C)CC3)N=C2)=CC4=C1C(C)=CN4C(C)C)NCC5=C(C)C=C(C)NC5=O

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Amount: 100 mg

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