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(+)-JQ1

(+)-JQ1

Item no.	V0411-50mg
Manufacturer	InvivoChem LLC
CASRN	1268524-70-4
Amount	50 mg
Quantity options	100 mg 10 mg 1 g 250 mg 25 mg 500 mg 5 mg
Category	Metabolism Diabetes Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0411CAS #:1268524-70-4 Purity >=98% Description: (+)-JQ1 is a novel, potent and highly specific BET (Bromodomain and extra terminal domain) bromodomain inhibitor with antineoplastic activity. It inhibits BRD4(1/2) with an IC50 of 77 nM and 33 nM in enzymatic assays. It has high specificity for BET in that it only binds to bromodomains of the BET family, but not to any bromodomains of non-BET family. (+)-JQ1 has potential antineoplastic activity against various cancers such as MM (Multiple myeloma), pancreatic ductal adenocarcinoma and ovarian cancer etc. Its mechanism of action is to inhibit c-MYC and upregulate p21. (+)-JQ1 has been used as a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. Description: References: Nature. 2010 Dec 23; 468(7327):1067-73; Cell. 2011 Sep 16; 146(6):904-17; Proc Natl Acad Sci U S A. 2011 Oct 4; 108(40):16669-74. References: Related CAS: 1268524-71-5 (-)-JQ-1; 202592-23-2 (+)-JQ1 carboxylic acid; 2115701-93-2 (+)-JQ1 PA;
Molecular Weight (MW)	456.99
Formula	C23H25ClN4O2S
CAS No.	1268524-70-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 91 mg/mL (199.1 mM)
	Water: < 1 mg/mL
	Ethanol: 91 mg/mL (199.1 mM)
Solubility (In vivo)	2% DMSO+30% PEG 300+5% Tween 80+ddH2O: 5 mg/mL
Synonyms	Bromodomain Inhibitor; (+)-JQ 1; (+)-JQ-1; (+)-JQ1;
SMILES Code	O=C(OC(C)(C)C)C[CH]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1
Chemical Name	tert-butyl (S)-2-(4-(4-chlorophenyl)-2, 3, 9-trimethyl-6H-thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a][1, 4]diazepin-6-yl) acetate

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Amount: 50 mg

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Delivery expected until 10/2/2025

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