PFI-4

Item no.	V0416-100mg
Manufacturer	InvivoChem LLC
CASRN	900305-37-5
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0416CAS #:900305-37-5Purity >=98% Description: PFI-4 is a novel, potent, cell permeable and selective inhibitor of bromodomain and PHD finger-containing protein 1 (BRPF1) with antineoplastic activity. It inhibits BRPF1 with an IC50 of 80 nM. PFI-4 aacts by specifically binding to BRPF1B with a Kd =13 nM as determined by ITC. It reduces recovery time in triple BRD cell construct in FRAP and is potent in cells with IC50 of 250nM, while showing no effect on BRPF1A. BRPF1A may act as dominant negative isoform of BRPF1 generated by alternative splicing. BRPF1 exists in 2 different isoforms: BRPF1A and BRPF1B. A residue insertion in the ZA loop of BRPF1A prevents binding to acetylated histone peptides. BRPF1A may act as dominant negative isoform of BRPF1 generated by alternative splicing. Description: References: ACS Med Chem Lett. 2014 Sep 10; 5(11):1190-5. References:
Molecular Weight (MW)	380.44
Formula	C21H24N4O3
CAS No.	900305-37-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 17 mg/mL (44.7 mM)
	Water: < 1 mg/mL
	Ethanol: 5 mg/mL (13.1 mM)
Other info	Chemical Name: N-[2, 3-Dihydro-1, 3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide InChi Key: QCIJLRJBZDBVDB-UHFFFAOYSA-N InChi Code: InChI=1S/C21H24N4O3/c1-23-17-12-15(22-20(26)14-8-4-5-9-19(14)28-3)16(25-10-6-7-11-25)13-18(17)24(2)21(23)27/h4-5, 8-9, 12-13H, 6-7, 10-11H2, 1-3H3, (H, 22, 26) SMILES Code: O=C(NC1=C(N2CCCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC
Synonyms	PFI 4; PFI4; PFI-4.

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Amount: 100 mg

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