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GSK1324726A (I-BET-726)

GSK1324726A (I-BET-726)

Item no.	V0422-50mg
Manufacturer	InvivoChem LLC
CASRN	1300031-52-0
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0422CAS #:1300031-52-0Purity >=98% Description: GSK1324726A (I-BET726; GSK-1324726A), a tetrahydroquinoline analog, is a novel and potent ApoA1 up-regulator and selective BET Bromodomain inhibitor with anticancerand anti-inflammatory activity. It inhibits BRD2/3/4 with IC50s of 41 nM, 31 nM, and 22 nM, respectively. It has potent in vitro antiproliferative and anti-inflammatory effects which translate into in vivo efficacy in oncology and inflammation models. Description: References: J Med Chem. 2018 Jan 25; 61(2):504-513; PLoS One. 2013 Aug 23; 8(8):e72967; J Med Chem. 2014 Oct 9; 57(19):8111-31. References:
Molecular Weight (MW)	434.91
Formula	C25H23ClN2O3
CAS No.	1300031-52-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 86 mg/mL (197.7 mM)
	Water: < 1 mg/mL
	Ethanol: 86 mg/mL (197.7 mM)
SMILES	ClC1=CC=C(N[CH]2C3=C(C=CC(C4=CC=C(C(O)=O)C=C4)=C3)N(C(C)=O)[CH](C)C2)C=C1
Synonyms	GSK1324726A, I-BET726, I-BET-726, I-BET 726, GSK-1324726A, GSK 1324726A Chemical Name: 4-[(2S, 4R)-1-Acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1, 2, 3, 4-tetrahydro-6-quinolinyl]benzoic acid Exact Mass: 434.1397

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 mg

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