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DEL-22379

DEL-22379

Item no.	V0469-10mg
Manufacturer	InvivoChem LLC
CASRN	181223-80-3
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0469CAS #:181223-80-3Purity >=98% Description: DEL-22379 is a novel, potent, selective, and water-soluble ERK (extracellular signal-related kinase 2) dimerization inhibitor with potential antitumor activity. It inhibits ERK with an IC50 of 0.5 uM. Unregulated RAS-ERK signaling is observed in nearly 50% of human malignancies and thus is an excellent target for intervention by antineoplasticagents. DEL-22379 inhibits ERK dimerization without affecting ERK phosphorylation, forestalls tumorigenesis driven by RAS-ERK pathway oncogenes. DEL-22379 readily binds to ERK2 with a Kd estimated in the low micromolar range, though binding is detectable even at low nanomolar concentrations. Description: References: Cancer Cell. 2015 Aug 10; 28(2):170-82. References:
Molecular Weight (MW)	444.53
Formula	C26H28N4O3
CAS No.	181223-80-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 89 mg/mL (200.2 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: (E)-N-(3-((5-methoxy-1H-indol-3-yl)methylene)-2-oxoindolin-5-yl)-3-(piperidin-1-yl)propanamide InChi Key: INQUULPXCZAKMS-LPYMAVHISA-N InChi Code: InChI=1S/C26H28N4O3/c1-33-19-6-8-23-20(15-19)17(16-27-23)13-22-21-14-18(5-7-24(21)29-26(22)32)28-25(31)9-12-30-10-3-2-4-11-30/h5-8, 13-16, 27H, 2-4, 9-12H2, 1H3, (H, 28, 31)(H, 29, 32)/b22-13+ SMILES Code: O=C(NC1=CC2=C(NC(/C2=C/C3=CNC4=C3C=C(OC)C=C4)=O)C=C1)CCN5CCCCC5
Synonyms	DEL 22379; DEL22379; DEL-22379.

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Amount: 10 mg

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Delivery expected until 9/4/2025

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