Anisomycin (NSC-76712, AI 3-50846, Flagecidin, Wuningmeisu C)

Description: Anisomycin (Wuningmeisu C, NSC76712, AI3-50846, Flagecidin), a naturally occuring bacterial antibiotic isolated from Streptomyces griseolus, is a novel, potent and specific activator (agonist) of JNK (c-Jun N-terminal Kinase) with potential antineoplastic activity. It is also a potent and reversibleinhibitor of protein synthesis in eukaryotic organisms that acts bybinding and inhibiting peptidyl transferase activity of 60S ribosomalsubunit.

References: Mol Cell Biol. 1997 Jun; 17(6):3373-81; Biochem Biophys Res Commun. 2014 Jan 10; 443(2):761-7.

Wuningmeisu C; NSC 76712; AI3 50846; NSC-76712; AI-350846; NSC76712; AI350846; Flagecidin;

Chemical Name: (2R, 3S, 4S)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidin-3-yl acetate

InChi Key: YKJYKKNCCRKFSL-RDBSUJKOSA-N

InChi Code: InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6, 12-15, 17H, 7-8H2, 1-2H3/t12-, 13+, 14+/m1/s1

SMILES Code: O[CH]1[CH](OC(C)=O)[CH](CC2=CC=C(OC)C=C2)NC1