TAK-715

Description: TAK-715 is a novel, potent and selective p38 MAPK (p38 mitogen-activated protein) inhibitor with potential anti-inflammatory activity. It inhibits p38alpha with an IC50 of 7.1 nM, and is 28-fold more selective for p38alpha over p38beta, it shows no/little inhibition against p38gamma/delta, JNK1, ERK1, IKKbeta, MEKK1 or TAK1. TAK-715 is currently under clinical investigation for the treatment of Rheumatoid arthritis-RA.

References: J Med Chem. 2005 Sep 22; 48(19):5966-79; Chem Biol. 2011 Apr 22; 18(4):485-94.

Synonym: TAK 715, TAK715, TAK-715

Chemical Name: N-(4-(2-ethyl-4-(m-tolyl)thiazol-5-yl)pyridin-2-yl)benzamide

InChi Key: HEKAIDKUDLCBRU-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H21N3OS/c1-3-21-27-22(18-11-7-8-16(2)14-18)23(29-21)19-12-13-25-20(15-19)26-24(28)17-9-5-4-6-10-17/h4-15H, 3H2, 1-2H3, (H, 25, 26, 28)

SMILES Code: O=C(NC1=NC=CC(C2=C(C3=CC=CC(C)=C3)N=C(CC)S2)=C1)C4=CC=CC=C4