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SKLB1002 (SKLB-1002; SKLB 1002)

SKLB1002 (SKLB-1002; SKLB 1002)

Item no.	V0500-100mg
Manufacturer	InvivoChem LLC
CASRN	1225451-84-2
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0500CAS #:1225451-84-2Purity >=98% Description: SKLB1002 (SKLB-1002; SKLB 1002) is a novel, potent and ATP-competitive VEGFR2 (VEGF receptor 2) inhibitor with potential antitumor activity. It inhibits VEGFR2 with an IC50 of 32 nM. It exhibits excellent anti-proliferative activity in vitro and high in vivo antitumor efficacy in mice bearing SW620 or HepG2 tumors. Description: ice bearing SW620 or HepG2 tumors. References: Clin Cancer Res. 2011 Jul 1; 17(13):4439-50; Clin Exp Med. 2014 May; 14(2):203-13. References:
Molecular Weight (MW)	320.39
Formula	C13H12N4O2S2
CAS No.	1225451-84-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 7 mg/mL (21.8 mM)
	Water:< 1 mg/mL
	Ethanol: < 1 mg/mL
SMILES	CC1=NN=C(SC2=C3C=C(OC)C(OC)=CC3=NC=N2)S1
Synonyms	SKLB 1002; SKLB1002; SKLB-1002; 2-((6, 7-dimethoxyquinazolin-4-yl)thio)-5-methyl-1, 3, 4-thiadiazole InChi Key: RQVGFDBMONQTBC-UHFFFAOYSA-N InChi Code: InChI=1S/C13H12N4O2S2/c1-7-16-17-13(20-7)21-12-8-4-10(18-2)11(19-3)5-9(8)14-6-15-12/h4-6H, 1-3H3 SMILES Code: CC1=NN=C(SC2=C3C=C(OC)C(OC)=CC3=NC=N2)S1

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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