Lapatinib Ditosylate (GW-572016, Tykerb)

Description: Lapatinib Ditosylate (formerly GW-572016, GW572016; trade names Tykerb and Tyverb) is an orally bioavailable medication acting as an EGFR (epidermal growth factor receptor) and ErbB2 inhibitor with antineoplastic activity. It inhibits EGFR and ErbB2 with IC50s of 10.8 and 9.2 nM in cell-free assays, respectively. It is an FDA approved drug for treating breast cancer and other solid tumors.

References: Mol Cancer Ther. 2001 Dec; 1(2):85-94; Cancer Res. 2006 Feb 1; 66(3):1630-9.

Related CAS: 231277-92-2 (free base); 388082-77-7 (ditosylate)

Chemical Name: N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine ditosylate

InChi Key: UWYXLGUQQFPJRI-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H26ClFN4O4S.2C7H8O3S/c1-40(36, 37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19; 2*1-6-2-4-7(5-3-6)11(8, 9)10/h2-10, 13-15, 18, 32H, 11-12, 16-17H2, 1H3, (H, 33, 34, 35); 2*2-5H, 1H3, (H, 8, 9, 10)

SMILES Code: O=S(CCNCC1=CC=C(C2=CC3=C(NC4=CC=C(OCC5=CC=CC(F)=C5)C(Cl)=C4)N=CN=C3C=C2)O1)(C)=O.OS(=O)(C6=CC=C(C)C=C6)=O.OS(=O)(C7=CC=C(C)C=C7)=O