AZ5104

Item no.	V0541-500mg
Manufacturer	InvivoChem LLC
CASRN	1421373-98-9
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Cardiovascular Research Ischemia & Reperfusion Injury Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0541CAS #:1421373-98-9Purity >=98% Description: AZ5104 (AZ-5104), a demethylated and active metabolite of Osimertinib (AZD-9291), is an irreversible EGFR inhibitor with potential antitumor activity. It inhibits EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR and ErbB4 with IC50s of 1, 6, 1, 25 and 7 nM, respectively. AZD9291 is a novel and selective third-generation irreversible inhibitor of both EGFRm(+) sensitizing and T790M resistance mutants that spares wild-type EGFR. References: Cancer Discov. 2014 Sep; 4(9):1046-61.
	Name: AZ5104 (Osimertinib metabolite) CAS#: 1421373-98-9 Chemical Formula: C27H31N7O2 Exact Mass: 485.25392 Molecular Weight: 485.58 Elemental Analysis: C, 66.78; H, 6.43; N, 20.19; O, 6.59
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: Demethylated AZ9291; active metabolite of AZD9291 (Osimertinib); AZ5104; AZ-5104; Chemical Name: N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide InChi Key: IQNVEOMHJHBNHC-UHFFFAOYSA-N InChi Code: InChI=1S/C27H31N7O2/c1-6-26(35)30-22-15-23(25(36-5)16-24(22)34(4)14-13-33(2)3)32-27-28-12-11-21(31-27)19-17-29-20-10-8-7-9-18(19)20/h6-12, 15-17, 29H, 1, 13-14H2, 2-5H3, (H, 30, 35)(H, 28, 31, 32) SMILES Code: C=CC(NC1=CC(NC2=NC=CC(C3=CNC4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C)=O.

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Amount: 500 mg

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