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Sapitinib (AZD-8931)

Sapitinib (AZD-8931)

Item no.	V0567-100mg
Manufacturer	InvivoChem LLC
CASRN	848942-61-0
Amount	100 mg
Quantity options	250 mg 25 mg 500 mg 50 mg 5 mg
Category	Cardiovascular Research Myocardial Infarction Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0567CAS #:848942-61-0Purity >=98% Description: Sapitinib (formerly AZD8931; AZD-8931) is an orally bioactive, reversible and ATP competitive inhibitor of multiple kinases including EGFR, ErbB2/3 with potential antitumor activity. It inhibits EGFR, ErbB2/3 with IC50s of 4 nM, 3 nM and 4 nM in cell-free assays. It shows potent anti-proliferative activity in vitro against NSCLC cells. Description: References: Clin Cancer Res. 2010 Feb 15; 16(4):1159-69. References: Related CAS: 1196531-39-1 (difumarate)
Molecular Weight (MW)	473.93
Formula	C23H25ClFN5O3
CAS No.	848942-61-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 40 mg/mL (84.4 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% propylene glycol: 5 mg/mL
Synonyms	AZD 8931; Sapitinib; AZD 8931; AZD8931; Chemical Name: 2-(4-((4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)-N-methylacetamide SMILES Code: O=C(NC)CN1CCC(OC2=CC3=C(NC4=CC=CC(Cl)=C4F)N=CN=C3C=C2OC)CC1

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Amount: 100 mg

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Delivery expected until 10/2/2025

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