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UNC-2025 HCl

UNC-2025 HCl

Item no.	V0586-50mg
Manufacturer	InvivoChem LLC
CASRN	2070015-17-5
Amount	50 mg
Quantity options	100 mg 10 mg 1 g 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0586CAS #:1429881-91-3 (free base)Purity >=98% Description: UNC-2025 HCl (known also as UNC2025), the Hydrochloride salt of UNC-2025, is an orally bioavailable and selective MER/FLT3 dual inhibitor with potential antineoplastic activity. It inhibits MER/FLT3 kinases with IC50s of 0.74 nM and 0.8 nM, respectively. UNC 2025 displayed about 20-fold selectivity for inhibiting MER/FLT3 over Axl and Tyro3. UNC-2025 is also capable of inhibiting Mer phosphorylation in vivo and shows potent anti-proliferative activity in vitro and high in vivo antitumor efficacy. Description: References: J Med Chem. 2014 Aug 28; 57(16):7031-41; Mol Cancer Ther. 2015 Sep; 14(9):2014-22. References:
Molecular Weight (MW)	513.12
Formula	C28H41ClN6O
CAS No.	1429881-91-3 (free base)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 25 mg/mL (48.7 mM)
	Water: 100 mg/mL (194.9 mM)
	Ethanol: 8 mg/mL (15.6 mM)
SMILES	CN1CCN(CC2=CC=C(C3=CN([CH]4CC[CH](O)CC4)C5=NC(NCCCC)=NC=C53)C=C2)CC1.[H]Cl
Synonyms	UNC-2025 HCl; UNC-2025 hydrochloride; UNC2025 hydrochloride; UNC 2025 HCl; UNC2025 HCl; UNC 2025 hydrochloride; UNC-2025, UNC2025, UNC 2025

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 mg

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Delivery expected until 10/2/2025

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