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SGX-523

SGX-523

Item no.	V0593-500mg
Manufacturer	InvivoChem LLC
CASRN	1022150-57-7
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0593CAS #:1022150-57-7Purity >=98% Description: SGX-523 (SGX 523; SGX523) is a novel, exquisitely selective, and ATP-competitive inhibitor of Hepatocyte growth factor receptor/Met with potential anticancer activity. It inhibits the tyrosine kinase Met with an IC50 of 4 nM, and exhibits no activity against BRAFV599E, c-Raf, Abl and p38alpha. MET is implicated in the development and progression of various cancer types. Description: References: Mol Cancer Ther. 2009 Dec; 8(12):3181-90. References:
Molecular Weight (MW)	359.41
Formula	C18H13N7S
CAS No.	1022150-57-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 3 mg/mL (8.3 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	0.5% methylcellulose+0.2% Tween 80: 30 mg/mL
Synonyms	SGX-523; SGX 523; SGX523; Chemical Name: 6-((6-(1-methyl-1H-pyrazol-4-yl)-[1, 2, 4]triazolo[4, 3-b]pyridazin-3-yl)thio)quinoline SMILES Code: CN1N=CC(C2=NN3C(C=C2)=NN=C3SC4=CC=C5N=CC=CC5=C4)=C1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 mg

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