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GSK1838705A

GSK1838705A

Item no.	V0608-100mg
Manufacturer	InvivoChem LLC
CASRN	1116235-97-2
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Cardiovascular Research Hypertension Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0608CAS #:1116235-97-2Purity >=98% Description: GSK1838705A (GSK-1838705A) is a novel, potent and reversible small-molecule IGF-1R inhibitor with potential anticancer activity. It inhibits IGF-1R with IC50 of 2.0 nM. GSK1838705A is modestly potent against IR and ALK with IC50s of 1.6 nM and 0.5 nM, respectively, and exhibits little activity to other protein kinases. Description: References: Mol Cancer Ther. 2009 Oct; 8(10):2811-20. References:
Molecular Weight (MW)	532.57
Formula	C27H29FN8O3
CAS No.	1116235-97-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 107 mg/mL (200.9 mM)
	Water: < 1 mg/mL
	Ethanol:< 1 mg/mL
Solubility (In vivo)	15% Captisol+citrate vehicle: 30 mg/mL
Synonyms	GSK-1838705A; GSK 1838705A; GSK1838705A; 2-((2-((1-(2-(dimethylamino)acetyl)-5-methoxyindolin-6-yl)amino)-7H-pyrrolo[2, 3-d]pyrimidin-4-yl)amino)-6-fluoro-N-methylbenzamide InChi Key: HZTYDQRUAWIZRE-UHFFFAOYSA-N InChi Code: InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8, 10, 12-13H, 9, 11, 14H2, 1-4H3, (H, 29, 38)(H3, 30, 31, 32, 33, 34) SMILES Code: O=C(NC)C1=C(F)C=CC=C1NC2=C3C(NC=C3)=NC(NC4=CC5=C(C=C4OC)CCN5C(CN(C)C)=O)=N2

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Amount: 100 mg

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Delivery expected until 10/2/2025

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