Comparison

Felodipine (CGH869)

Item no. V0619-1g
Manufacturer InvivoChem LLC
CASRN 72509-76-3
Amount 1 g
Quantity options 100 mg 250 mg 500 mg 50 mg 5 g
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Available
Description
InvivoChem Cat #:V0619CAS #:72509-76-3 Purity >=98%

Description: Felodipine (formerly also known as CGH-869; trade names Plendil, Renedil etc.), a marketed anti-hypertensive drug, is a potent, selective and long-acting L-type Ca2+ channel blocker (CCB) of the 1, 4-dihydropyridine (DHP) class with an IC50 of 0.15 nM. It was approved to treat high blood pressure in 1988. Felodipine is described to inhibit cytokine-induced NO and superoxide production as well as cytokine-induced NO synthase (NOS) mRNA induction, and is suggested to act as a scavenger of superoxide and not an inhibitor of inducible NOS induction. This indicates that Felodipine further protects the vasculature against endogenous free radical generation during inflammatory responses.

References: J Pharmacol Exp Ther. 1983 Aug; 226(2):330-4; J Mol Cell Cardiol. 1995 Oct; 27(10):2295-302.

Molecular Weight (MW)
384.25
Formula
C18H19Cl2NO4
CAS No.
72509-76-3
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Solubility (In vitro)
DMSO: 77 mg/mL (200.4 mM)
Water: < 1 mg/mL
Ethanol: 77 mg/mL (200.4 mM)
Other info

Chemical Name: (RS)-3-ethyl 5-methyl 4-(2, 3-dichlorophenyl)-2, 6-dimethyl-1, 4-dihydropyridine-3, 5-dicarboxylate

InChi Key: RZTAMFZIAATZDJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8, 15, 21H, 5H2, 1-4H3

SMILES Code: O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC(Cl)=C2Cl)OCC

Synonyms
CGH-869; Perfudal, Plendil, Renedil, Felodipine, CGH 869; Felobeta, CGH869; Agon, Felo-Puren, Felocor, Felodipin, Felodur Felogamma, Fensel, Flodil, Modip, Munobal,

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 1 g
Available: In stock
available

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