BMS-536924 (CS0117; BMS 536924)

Description: BMS-536924 (also called CS-0117; BMS536924; CS0117) is a novel, potent and ATP-competitive small molecule inhibitor of IGF-1R/IR with potential anticancer activity. It inhibits IGF-1R/IR with IC50 of 100 nM/73 nM. BMS-536924 showed modest activity against Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2. BMS-536924 exhibits potent antitumor activity in various tumor models such as sarcoma and IGR-1R Sal tumor model.

References: J Med Chem. 2005 Sep 8; 48(18):5639-43; Clin Cancer Res. 2009 Jan 1; 15(1):226-37.

Chemical Name: (S)-4-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one

SMILES Code: O=C1C(C2=NC3=C(C)C=C(N4CCOCC4)C=C3N2)=C(NC[CH](C5=CC=CC(Cl)=C5)O)C=CN1