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GNF-5837

GNF-5837

Item no.	V0641-250mg
Manufacturer	InvivoChem LLC
CASRN	1033769-28-6
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg
Category	Cardiovascular Research Thrombosis & Hemostasis Atherosclerosis Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0641CAS #:1033769-28-6Purity >=98% Description: GNF-5837 (GNF5837) is an orally bioavailable pan-TRK (TrkA, TrkB) inhibitor with potential antitumor activity. It inhibits TrkA/B with IC50s of 8 nM, and 12 nM, respectively. GNF-5837 demonstrates high anti-proliferative activity in vitro against Ba/F3 cells with an IC50 of 0.042 uM. GNF-5837 shows high in vivo antitumor efficacy in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. Description: References: ACS Med Chem Lett. 2012 Jan 1; 3(2):140-5. References:
Molecular Weight (MW)	535.49
Formula	C28H21F4N5O2
CAS No.	1033769-28-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (186.7 mM)
	Water: < 1 mg/mL
	Ethanol: 9 mg/mL(16.8 mM)
Other info	Chemical Name: (Z)-1-(3-((3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea InChi Key: YYDUWLSETXNJJT-MTJSOVHGSA-N InChi Code: InChI=1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30, 31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14, 33-34H, 1H3, (H, 36, 38)(H2, 35, 37, 39)/b21-12- SMILES Code: O=C(NC1=CC(C(F)(F)F)=CC=C1F)NC2=CC=C(C)C(NC3=CC(NC/4=O)=C(C=C3)C4=C\C5=CC=CN5)=C2
Synonyms	GNF-5837; GNF 5837; GNF5837;

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Amount: 250 mg

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Delivery expected until 10/2/2025

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