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Piceatannol (Astringenin; NSC-622471; trans-Piceatannol)

Piceatannol (Astringenin; NSC-622471; trans-Piceatannol)

Item no.	V0654-1g
Manufacturer	InvivoChem LLC
CASRN	10083-24-6
Amount	1 g
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0654CAS #:10083-24-6Purity >=98% Description: Piceatannol (also known as Astringenin; NSC-622471; trans-Piceatannol), a naturally occuring stilbene, is a potent and selective Syk inhibitor and shows ca.10-fold selectivity for Srk over Lyn. It has anti-inflammatory, immunomodulatory and antiproliferative activities. Piceatannol demonstrated high in vivo anti-inflammatory activity in female BALB/c mice with dextran sulfate sodium (DSS)-induced colitis. It inhibits p56lck and syk protein tyrosine kinases and inhibits TNF-induced NF-kappaB activation and gene expression. Synthesis results from conversion of resveratrol by cytochrome P450 1B1. Description:emale BALB/c mice with dextran sulfate sodium (DSS)-induced colitis. References: J Biol Chem. 1994 Nov 25; 269(47):29697-703.; Int Immunopharmacol. 2008 Dec 10; 8(12):1695-702. References:
Molecular Weight (MW)	244.24
Formula	C14H12O4
CAS No.	10083-24-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 48 mg/mL (196.5 mM)
	Water: < 1 mg/mL
	Ethanol: < 48 mg/mL (196.5 mM)
Solubility (In vivo)	1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL
Synonyms	Synonym: NSC 622471; NSC-622471; Piceatannol; NSC622471. Chemical Name: (E)-4-[2-(3, 5Dihydroxyphenyl)ethenyl]1, 2-benzenediol, 3, 3?, 4, 5?-Tetrahydroxy-trans-stilbene InChi Key: CDRPUGZCRXZLFL-OWOJBTEDSA-N InChi Code: InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8, 15-18H/b2-1+ SMILES Code: c1(c(ccc(\C=C\c2cc(O)cc(c2)O)c1)O)O

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