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EPOXOMICIN (BU 4061T)

EPOXOMICIN (BU 4061T)

Item no.	V0689-100mg
Manufacturer	InvivoChem LLC
CASRN	134381-21-8
Amount	100 mg
Quantity options	10 mg 1 mg 25 mg 2 mg 500 ug 50 mg 5 mg
Category	Cardiovascular Research Ischemia & Reperfusion Injury Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0689CAS #:134381-21-8Purity >=98% Description: Epoxomicin (formerly also known as BU-4061T) is a novel, potent, selective, cell-permeable and irreversible proteasome inhibitor with anti-inflammatory activity, it inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH catalytic activities are also inhibited at 100- and 1000-fold reduced rate. The novel alpha-epoxy ketone moiety of Epoxomicin forms covalent bonds with residues in particular catalytic subunits of the enzyme, disabling activity. References: Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):10403-8.
Molecular Weight (MW)	554.72
Formula	C28H50N4O7
CAS No.	134381-21-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (180.3 mM)
	Water: < 1 mg/mL
	Ethanol: 100 mg/mL (180.3 mM)
Other info	Chemical Name: (2S, 3S)-2-[[(2S, 3S)-2-[Acetyl(methyl)amino]-3-methylpentanoyl]amino]-N-[(2S, 3R)-3-hydroxy-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxobutan-2-yl]-3-methylpentanamide InChi Key: DOGIDQKFVLKMLQ-JTHVHQAWSA-N InChi Code: InChI=1S/C28H50N4O7/c1-11-16(5)21(30-27(38)23(17(6)12-2)32(10)19(8)34)25(36)31-22(18(7)33)26(37)29-20(13-15(3)4)24(35)28(9)14-39-28/h15-18, 20-23, 33H, 11-14H2, 1-10H3, (H, 29, 37)(H, 30, 38)(H, 31, 36)/t16-, 17-, 18+, 20-, 21-, 22-, 23-, 28+/m0/s1 SMILES Code: CC[CH](C)[CH](NC([CH](N(C(C)=O)C)[CH](C)CC)=O)C(N[CH]([CH](O)C)C(N[CH](CC(C)C)C([C]1(C)OC1)=O)=O)=O
Synonyms	BU-4061T; BU 4061T; BU4061T; EPOXOMICIN;

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Amount: 100 mg

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