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DELANZOMIB (CEP18770)

DELANZOMIB (CEP18770)

Item no.	V0692-250mg
Manufacturer	InvivoChem LLC
CASRN	847499-27-8
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0692CAS #:847499-27-8Purity >=98% Description: Delanzomib (formerly known as CEP-18770) is a novel, potent, and orally bioactive inhibitor of the chymotrypsin-like (CL) activity of proteasome with potential antineoplastic activity. It inhibits CL-proteasome with an IC50 of 3.8 nM, and shows little inhibition against the tryptic and peptidylglutamyl activities of the proteosome. It demonstrate significant in vivo antitumor efficacy in human MM RPMI 8226 subcutaneous xenograft model in SCID mice. It demonstrate significant in vivo antitumor efficacy in human MM RPMI 8226 subcutaneous xenograft model in SCID mice References: Blood. 2008 Mar 1; 111(5):2765-75; Br J Haematol. 2010 Feb; 148(4):569-81; Nat Methods. 2005 May; 2(5):357-62.
Molecular Weight (MW)	413.28
Formula	C21H28BN3O5
CAS No.	847499-27-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 83 mg/mL (200.8 mM)
	Water: < 1 mg/mL
	Ethanol: 83 mg/mL (200.8 mM)
Solubility (In vivo)	Chemical Name: [(1R)-1-[[(2S, 3R)-3-Hydroxy-2-[[(6-phenylpyridin-2-yl)carbonyl]amino]-1-oxobutyl]amino]-3-methylbutyl]boronic acid. InChi Key: SJFBTAPEPRWNKH-CCKFTAQKSA-N InChi Code: InChI=1S/C21H28BN3O5/c1-13(2)12-18(22(29)30)24-21(28)19(14(3)26)25-20(27)17-11-7-10-16(23-17)15-8-5-4-6-9-15/h4-11, 13-14, 18-19, 26, 29-30H, 12H2, 1-3H3, (H, 24, 28)(H, 25, 27)/t14-, 18+, 19+/m1/s1 SMILES Code: CC(C)C[CH](B(O)O)NC([CH](NC(C1=NC(C2=CC=CC=C2)=CC=C1)=O)[CH](O)C)=O
Synonyms	CEP18770; CEP 18770; CEP-18770; Delanzomib

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Amount: 250 mg

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Delivery expected until 10/2/2025

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