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Description: Nafamostat mesylate (formerly also known as FUT-175) is a novel and synthetic serine protease inhibitor, which is used as a short-acting anticoagulant during hemodialysis. Nafamostat promotes endothelium-dependent vasorelaxation via the Akt-eNOS dependent pathway. Nafamostat mesylate can also be used for the treatment ofpancreatitis and has antiviral and anti-canceractivity.
References: Thromb Haemost. 1996 Jan; 75(1):76-82; Eur J Pharmacol. 2006 Jan 13; 530(1-2):172-8.
Related CAS #: 80251-32-7 (HCl) 81525-10-2 (free base) 82956-11-4 (mesylate)
Chemical Name: 6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate
InChi Key: SRXKIZXIRHMPFW-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23; 2*1-5(2, 3)4/h1-10H, (H3, 20, 21)(H4, 22, 23, 24); 2*1H3, (H, 2, 3, 4)
SMILES Code: CS(=O)(O)=O.CS(=O)(O)=O.O=C(OC1=CC=C2C=C(C(N)=N)C=CC2=C1)C3=CC=C(NC(N)=N)C=C3
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