DAPT (GSI-IX; LY374973)

Description: DAPT (also known as GSI-IX; LY-374973) is a novel, potent and selective gamma-secretase inhibitor used in the study of the Notch signaling pathway and is reported to be able to reduce the levels of beta-amyloid in a mouse model of Alzheimer's disease. DAPT acts by indirectly inhibiting Notch, which is a substrate of gamma-secretase, leading to the inhibition of Abeta production with an IC50 of 20 nM in HEK 293 cells.

References: J Neurochem. 2001 Jan; 76(1):173-81; APMIS. 2012 Jun; 120(6):441-50; Neuroscience. 2012 May 17; 210:99-109.

LY-374973, DAPT; LY 374973, LY374973, GSI-IX; DAPT peptide; GSI-IX; GSI IX; N-(2FPhAc)Ala-phenyl-Gly t-butyl ester.

Chemical Name: tert-butyl (S)-2-((S)-2-(2-(3, 5-difluorophenyl)acetamido)propanamido)-2-phenylacetate

InChi Key: DWJXYEABWRJFSP-XOBRGWDASA-N

InChi Code: InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2, 3)4/h5-11, 13-14, 20H, 12H2, 1-4H3, (H, 26, 28)(H, 27, 29)/t14-, 20-/m0/s1

SMILES Code: O=C(OC(C)(C)C)[CH](C1=CC=CC=C1)NC([CH](C)NC(CC2=CC(F)=CC(F)=C2)=O)=O