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MK-0752

MK-0752

Item no.	V0717-250mg
Manufacturer	InvivoChem LLC
CASRN	471905-41-6
Amount	250 mg
Quantity options	100 mg 10 mg 1 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0717CAS #:471905-41-6 Purity >=98% Description: MK0752 (MK0752; MK-0752) is a novel, potent and synthetic small molecule inhibitor of gamma-secretase (gamma-secretase). It reduces Abeta40 production with an IC50 of 5 nM and has potential anti-AD (Alzheimer's disease) and antineoplastic activity. References: J Neurosci. 2010 May 12; 30(19):6743-50; Cancer Res. 2010 Jan 15; 70(2):709-18. Related CAS: 656810-87-6 (sodium salt)
Molecular Weight (MW)	442.9
Formula	C21H21ClF2O4S
CAS No.	471905-41-6 (free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 89 mg/mL (200.9 mM)
	Water: < 1 mg/mL
	Ethanol: 45 mg/mL (101.6 mM)
Solubility (In vivo)	30% propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
Synonyms	MK0752; MK 0752; MK-0752 Chemical Name: 3-((1r, 4s)-4-((4-chlorophenyl)sulfonyl)-4-(2, 5-difluorophenyl)cyclohexyl)propanoic acid. InChi Key: XCGJIFAKUZNNOR-HNSKJHPRSA-N InChi Code: InChI=1S/C21H21ClF2O4S/c22-15-2-5-17(6-3-15)29(27, 28)21(18-13-16(23)4-7-19(18)24)11-9-14(10-12-21)1-8-20(25)26/h2-7, 13-14H, 1, 8-12H2, (H, 25, 26)/t14-, 21- SMILES Code: O=C(O)CC[CH]1CC[C](C2=CC(F)=CC=C2F)(S(=O)(C3=CC=C(Cl)C=C3)=O)CC1

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Amount: 250 mg

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Delivery expected until 9/4/2025

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