Lomibuvir (VX 222; VCH 222)

Description: Lomibuvir (also known as Lomibuvir (also called VX-22; S-1480; VCH222; VX22; S1480; VX222; VCH-222; VX-222) is a novel, potent and selective non-nucleoside inhibitor/NNI of hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase with IC50s in the range of 0.94-1.2 uM. It has been investigatedin clinical trials for the treatment of chronic HCV and chronic HCV infections. ) is a novel, potent and selective non-nucleoside inhibitor/NNI of hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase with IC50s of 0.94-1.2 uM, it has been investigatedin clinical trials for the treatment of chronic HCV and chronic HCV infections.

References: Antimicrob Agents Chemother. 2012 Feb; 56(2):830-7; J Hepatol, 2009, 50(Suppl 1), S341-S342.

Chemical Name: 5-(3, 3-dimethylbut-1-yn-1-yl)-3-((1r, 4R)-N-((1r, 4R)-4-hydroxycyclohexyl)-4-methylcyclohexane-1-carboxamido)thiophene-2-carboxylic acid

SMILES Code: O=C(C1=C(N([CH]2CC[CH](O)CC2)C([CH]3CC[CH](C)CC3)=O)C=C(C#CC(C)(C)C)S1)O