WS3

Item no.	V0758-500mg
Manufacturer	InvivoChem LLC
CASRN	1421227-52-2
Amount	500 mg
Quantity options	100 mg 10 mg 1 g 250 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0758CAS #:1421227-52-2Purity >=98% Description: WS-3 (WS3; WS 3) is a novel and potent small molecule modulatior of Erb3 binding protein-1 (EBP1) and the IkappaB (IkappaB) kinase with important biological activity. It promotes beta-cell proliferation with an EC50 of 28 nM (induced R7T1 proliferation). In HEK cells stably expressing either hTRPM8 or hTRPA1, WS 3 activated hTRPM8 and hTRPA1 with EC50 values of 2.2 and 120.6 uM, respectively. WS 3 was efficacious in eliciting cooling sensation. References: Chem Senses. 2011 Sep; 36(7):649-58.; J Am Chem Soc. 2013 Feb 6; 135(5):1669-72; ACS Chem Biol. 2013 Jul 19; 8(7):1407-11.
Molecular Weight (MW)	569.58
Formula	C28H30F3N7O3
CAS No.	1421227-52-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (175.6 mM)
	Water: < 1 mg/mL
	Ethanol: 80 mg/mL warmed (140.5 mM)
Other	Chemical Name: N-(6-(4-(3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide InChi Key: KIKOYRNAERIVSJ-UHFFFAOYSA-N InChi Code: InChI=1S/C28H30F3N7O3/c1-37-10-12-38(13-11-37)16-19-4-5-21(14-23(19)28(29, 30)31)35-27(40)34-20-6-8-22(9-7-20)41-25-15-24(32-17-33-25)36-26(39)18-2-3-18/h4-9, 14-15, 17-18H, 2-3, 10-13, 16H2, 1H3, (H2, 34, 35, 40)(H, 32, 33, 36, 39) SMILES Code: CN1CCN(CC2=CC=C(NC(NC3=CC=C(OC4=CC(NC(C5CC5)=O)=NC=N4)C=C3)=O)C=C2C(F)(F)F)CC1
Synonyms	WS-3; WS 3; WS3;

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Amount: 500 mg

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