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Rolipram (ME 3167; ZK 62711; SB 95952)

Rolipram (ME 3167; ZK 62711; SB 95952)

Item no.	V0788-100mg
Manufacturer	InvivoChem LLC
CASRN	61413-54-5
Amount	100 mg
Quantity options	1 g 250 mg 2 g 500 mg 50 mg
Category	Neuroscience Molecular Targets for Neuroscience Neural Signaling Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0788CAS #:61413-54-5 Purity >=98% Description: Rolipram (formerly called ME-3167; ZK-62711; SB95952; the racemic mixture of R- and S-rolipram) is a novel, potent and selective phosphodiesterase PDE4 inhibitor with potential anti-inflammatory and anti-depressant activity. It inhibits PDE4A/4B/4D with IC50s of 3 nM, 130 nM and 240 nM, respectively. Description: References: Trends Pharmacol Sci. 1997 May; 18(5):164-71; Br J Pharmacol. 1996 Jun; 118(3):649-58; J Pharmacol Exp Ther. 1993 Jul; 266(1):306-13. References: Related CAS: 85416-75-7 (R-enantiomer of Rolipram); 85416-73-5 (S-enantiomer of Rolipram)
Molecular Weight (MW)	275.34
Formula	C16H21NO3
CAS No.	61413-54-5 (racemic);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 55 mg/mL (199.8 mM)
	Water:< 1 mg/mL
	Ethanol: 55 mg/mL (199.8 mM)
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% propylene glycol: 10 mg/L
Synonyms	ZK-62711; SB 95952; SB95952; SB-95952; ME-3167; ZK-62711; ME3167; ZK62711; ME 3167; ZK 62711 Chemical Name: 4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one InChi Key: HJORMJIFDVBMOB-UHFFFAOYSA-N InChi Code: InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8, 12-13H, 2-5, 9-10H2, 1H3, (H, 17, 18) SMILES Code: O=C1NCC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1

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Amount: 100 mg

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Delivery expected until 9/4/2025

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