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TAK-700/Orteronel (s-isomer)

TAK-700/Orteronel (s-isomer)

Item no.	V0819-250mg
Manufacturer	InvivoChem LLC
CASRN	566939-85-3
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0819CAS #:566939-85-3 Purity >=98% Description: Orterone (aslo known as TAK-700; TAK 700; TAK700) is an orally bioavailable non-steroidal androgen synthesis inhibitor of human 17, 20-lyase inhibitor with potential anticancer activity. It inhibits human 17, 20-lyase with IC50 of 38 nM, and exhibits > 1000-fold selectivity for human 17, 20-lyase over other CYPs (e.g. 11-hydroxylase and CYP3A4). It is a novel hormonal therapy developed by Takeda company for the treatment of prostate cancer. Description: References: Bioorg Med Chem. 2011 Nov 1; 19(21):6383-99; J Steroid Biochem Mol Biol. 2012 Apr; 129(3-5):115-28. References: Related CAS: 566939-85-3 (s-isomer); 426219-18-3 (racemic)
Molecular Weight (MW)	307.35
Formula	C18H17N3O2
CAS No.	566939-85-3 (s-isomer)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 61 mg/mL (198.5 mM)
	Water:< 1 mg/mL
	Ethanol: 8 mg/mL (26.0 mM)
Solubility (In vivo)	0.5% methylcellulose: 30 mg/mL
Synonyms	TAK700; TAK-700; TAK 700; Orteronel (s-isomer); Chemical Name: (S)-6-(7-hydroxy-6, 7-dihydro-5H-pyrrolo[1, 2-c]imidazol-7-yl)-N-methyl-2-naphthamide InChi Key: OZPFIJIOIVJZMN-SFHVURJKSA-N InChi Code: InChI=1S/C18H17N3O2/c1-19-17(22)14-3-2-13-9-15(5-4-12(13)8-14)18(23)6-7-21-11-20-10-16(18)21/h2-5, 8-11, 23H, 6-7H2, 1H3, (H, 19, 22)/t18-/m0/s1 SMILES Code: O=C(NC)C1=CC=C2C=C([C]3(O)CCN4C=NC=C43)C=CC2=C1

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Amount: 250 mg

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Delivery expected until 9/4/2025

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