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Description: Pralatrexate (PDX; trade name Folotyn), an antifolate which is structurally a folate analog, is a potent and selective inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate has been approved by FDA to treat a certain type of cancer called peripheral T-Cell lymphoma-PTCL.
References: Clin Cancer Res. 2010 Jul 15; 16(14):3648-58; Cancer Chemother Pharmacol. 2009 Oct; 64(5):993-9.
Related CAS: 146464-95-1 (racemic); 1320211-69-5 (S-isomer); 1320211-70-8 (R-isomer)
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