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Pralatrexate (racemic)

Pralatrexate (racemic)

Item no.	V0848-50mg
Manufacturer	InvivoChem LLC
CASRN	146464-95-1
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0848CAS #:146464-95-1 Purity >=98% Description: Pralatrexate (PDX; trade name Folotyn), an antifolate which is structurally a folate analog, is a potent and selective inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate has been approved by FDA to treat a certain type of cancer called peripheral T-Cell lymphoma-PTCL. Description: References: Clin Cancer Res. 2010 Jul 15; 16(14):3648-58; Cancer Chemother Pharmacol. 2009 Oct; 64(5):993-9. References: Related CAS: 146464-95-1 (racemic); 1320211-69-5 (S-isomer); 1320211-70-8 (R-isomer)
Molecular Weight (MW)	477.47
Formula	C23H23N7O5
CAS No.	146464-95-1(racemic);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 28 mg/mL (58.6 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: N -(4-{1-[(2, 4-diaminopteridin-6-yl)methyl]but-3-yn-1-yl}benzoyl)-L-glutamic acid InChi Key: OGSBUKJUDHAQEA-WMCAAGNKSA-N InChi Code: InChI=1S/C23H23N7O5/c1-2-3-14(10-15-11-26-20-18(27-15)19(24)29-23(25)30-20)12-4-6-13(7-5-12)21(33)28-16(22(34)35)8-9-17(31)32/h1, 4-7, 11, 14, 16H, 3, 8-10H2, (H, 28, 33)(H, 31, 32)(H, 34, 35)(H4, 24, 25, 26, 29, 30)/t14?, 16-/m0/s1 SMILES Code: O=C(O)CC[CH](C(O)=O)NC(C1=CC=C(C(CC2=NC3=C(N)N=C(N)N=C3N=C2)CC#C)C=C1)=O
Synonyms	PDX; Pralatrexate; 10-Propargyl-10-deazaaminopterin; trade name: Folotyn.

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Amount: 50 mg

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Delivery expected until 10/2/2025

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