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teriflunomide

teriflunomide

Item no.	V086-1g
Manufacturer	InvivoChem LLC
CASRN	108605-62-5
Amount	1 g
Quantity options	100 mg 10 g 250 mg 2 g 500 mg 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V086CAS #:108605-62-5Purity >=98% Description: Teriflunomide (formerly HMR-1726; HMR1726; A771726; A-771726; trade name Aubagio), the active metabolite of the immunomodulator drug-leflunomide, is an orally bioavailable immunomodulatory agent with potential suppressing effects against immune systems. It acts by blocking the enzyme dihydroorotate dehydrogenase, thus inhibiting pyrimidine de novo synthesis. Teriflunomide has been approved for the treatment of arthritis and multiple sclerosis (MS). Teriflunomide inhibits rapidly dividing cells, including activated T cells, which are thought to drive the disease process in MS. Description: References: Ther Clin Risk Manag. 2013; 9:177-90. References: Related CAS #: 163451-81-8
Molecular Weight (MW)	270.21
Formula	C12H9F3N2O2
CAS No.	108605-62-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 32 mg/mL (118.4 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: (Z)-2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide. InChi Key: UTNUDOFZCWSZMS-YFHOEESVSA-N InChi Code: InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13, 14)15/h2-5, 18H, 1H3, (H, 17, 19)/b10-7- SMILES Code: C/C(O)=C(C#N)/C(NC1=CC=C(C(F)(F)F)C=C1)=O
Synonyms	A77 1726, HMR-1726; A77 1726; Aubagio; A771726; A-771726; HMR1726; HMR 1726; teriflunomide; trade name: Aubagio.

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Amount: 1 g

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