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BIIB021

BIIB021

Item no.	V0877-500mg
Manufacturer	InvivoChem LLC
CASRN	848695-25-0
Amount	500 mg
Quantity options	100 mg 10 mg 1 g 250 mg 25 mg 2 g 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0877CAS #:848695-25-0 Purity >=98% Description: BIIB021 (CNF2024; BIIB-021; CNF-2024; CNF 2024; BIIB 021) is an orally bioavailable and purine-based small-molecule inhibitor of HSP90 (heat shock protein 90) with potential anticancer activity. It inhibits HSP90 with a Ki and an EC50 of 1.7 nM and 38 nM, respectively. BIIB021 exhibits excellent in vivo antitumor efficacy in many tumor xenograft models such as N87, BT474, CWR22, U87, SKOV3 and Panc-1. Description: BIIB021 exhibits excellent in vivo antitumor efficacy in many tumor xenograft models such as N87, BT474, CWR22, U87, SKOV3 and Panc-1. References: Mol Cancer Ther. 2009 Apr; 8(4):921-9; Clin Cancer Res. 2009 Aug 15; 15(16):5108-16; Int J Cancer. 2010 Mar 1; 126(5):1216-25. References: Related CAS: 848695-25-0 (free base); 1225041-97-3 (mesylate)
Molecular Weight (MW)	318.76
Formula	C₁₄H₁₅ClN₆O
CAS No.	848695-25-0(free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 64 mg/mL (200.8 mM)
	Water: < 1 mg/mL
	Ethanol: 2 mg/mL (6.27 mM)
Solubility (In vivo)	30% propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
Synonyms	CNF2024; BIIB-021; CNF-2024; CNF 2024; BIIB021; BIIB 021; Chemical Name: [6-Chloro-9-(4-methoxy-3, 5-dimethylpyridin-2-ylmethyl)-9H-purin-2-yl]amine InChi Key: QULDDKSCVCJTPV-UHFFFAOYSA-N InChi Code: InChI=1S/C14H15ClN6O/c1-7-4-17-9(8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21/h4, 6H, 5H2, 1-3H3, (H2, 16, 19, 20) SMILES Code: NC1=NC(Cl)=C2N=CN(CC3=NC=C(C)C(OC)=C3C)C2=N1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 mg

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Delivery expected until 10/2/2025

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