XL888

Item no.	V0887-10mg
Manufacturer	InvivoChem LLC
CASRN	1149705-71-4
Amount	10 mg
Quantity options	100 mg 1 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0887CAS #:1149705-71-4Purity >=98% Description: XL888 (XL-888; XL 888) is an orally bioavailable, ATP-competitive inhibitor of HSP90 (Heat Shock Protein 90) with potential antitumor activity. It inhibits HSP90 with an IC50 of 24 nM. It exhibits excellent in vivo antitumor efficacy in mice bearing M229R xenografts Description:ice bearing M229R xenografts References: Bioorg Med Chem Lett. 2012 Sep 1; 22(17):5396-404; Clin Cancer Res. 2012 May 1; 18(9):2502-14. References:
Molecular Weight (MW)	503.64
Formula	C29H37N5O3
CAS No.	1149705-71-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (198.6 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% propylene glycol: 30mg/mL
Synonyms	XL-888; XL 888; XL888; Chemical Name: 5-((R)-sec-butylamino)-N1-((1R, 3s, 5S)-8-(5-(cyclopropanecarbonyl)pyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl)-2-methylterephthalamide InChi Key: LHGWWAFKVCIILM-CIQXWFTPSA-N InChi Code: InChI=1S/C29H37N5O3/c1-4-17(3)32-25-14-23(16(2)11-24(25)28(30)36)29(37)33-20-12-21-8-9-22(13-20)34(21)26-10-7-19(15-31-26)27(35)18-5-6-18/h7, 10-11, 14-15, 17-18, 20-22, 32H, 4-6, 8-9, 12-13H2, 1-3H3, (H2, 30, 36)(H, 33, 37)/t17-, 20-, 21-, 22+/m1/s1 SMILES Code: O=C(NC1=CC=C(CCN2CC3=C(C=C(OC)C(OC)=C3)CC2)C=C1)C4=CC=CC(/C=C(C(N(C)/C5=C\C6=CC=CC=C6)=O)\NC5=O)=C

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Amount: 10 mg

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