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Description: Asenapine maleate (Org5222; Org-5222; HSDB-8061; HSDB8061; Saphris and Sycrest), an atypical antipsychotic, is a potent and high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors. Asenapine has been approved as an atypical antipsychotic for the treatment of schizophrenia and acute mania associated with bipolar disorders. Preliminary data indicate that it has minimal anticholinergic and cardiovascular side effects, as well as minimal weight gain. It was approved by FDA in August 2009.
References: J Psychopharmacol. 2009 Jan; 23(1):65-73; Psychopharmacology (Berl). 2008 Feb; 196(3):417-29.
Related CAS #: 85650-56-2 (maleate); 65576-45-6 (free); 1412458-61-7 (HCl)
Chemical Name: (3aS, 12bS)-5-chloro-2-methyl-2, 3, 3a, 12b-tetrahydro-1H-dibenzo[2, 3:6, 7]oxepino[4, 5-c]pyrrole maleate
InChi Key: GMDCDXMAFMEDAG-CHHFXETESA-N
InChi Code: InChI=1S/C17H16ClNO.C4H4O4/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19; 5-3(6)1-2-4(7)8/h2-8, 14-15H, 9-10H2, 1H3; 1-2H, (H, 5, 6)(H, 7, 8)/b; 2-1-/t14-, 15-; /m1./s1
SMILES Code: CN1C[C](C2=CC=CC=C2OC3=CC=C(Cl)C=C34)([H])[C]4([H])C1.O=C(O)/C=C\C(O)=O
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