Comparison

AZ-505 2TFA salt

Item no. V12013-25mg
Manufacturer InvivoChem LLC
CASRN 1035227-44-1
Amount 25 mg
Quantity options 100 mg 10 mg 50 mg 5 mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Available
Description
InvivoChem Cat #:V12013CAS #:1035227-44-1Purity >=98%

Description: AZ505 ditrifluoroacetate is a novel, potent and highly selective inhibitor of SMYD2 with an IC50 of 0.12 uM and with potential anticancer activity. AZ505 is composed of three benzooxazinone, cyclohexyl, and dichlorophenethyl substituents. The structure of the ternary complex reveals that a single AZ505 molecule is bound in the peptide binding groove of SMYD2.

References:

1. Komatsu S, et al. Overexpression of SMYD2 contributes to malignant outcome in gastric cancer. Br J Cancer. 2015 Jan 20; 112(2):357-64.

2. Ferguson AD, et al. Structural basis of substrate methylation and inhibition of SMYD2. Structure. 2011 Sep 7; 19(9):1262-73.

3. Li LX, et al. Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease. J Clin Invest. 2017 Jun 30; 127(7):2751-2764.

Related CAS #: 1035227-43-0 (free base) 1035227-44-1 (TFA)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 25 mg
Available: In stock
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