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SBE 13 HCl

SBE 13 HCl

Item no.	V1581-10mg
Manufacturer	InvivoChem LLC
CASRN	1052532-15-6
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1581CAS #:1052532-15-6Purity >=98% Description: SBE 13 HCl is a novel, potent and selective PLK1 inhibitor with IC50 of 200 pM, and shows > 4000-fold selectivity over Aurora A kinase, Plk2 and Plk3. SBE 13 decreases cell proliferation in various cancer cell lines, and causes a G2/M arrest followed by apoptosis. In primary cells, SBE 13 does not impair cell cycle and thus proliferation of primary cells. SBE13 in combination with Enzastaurin displays a synergistic reduction of cell proliferation and enhanced apoptosis induction in HCT116(p53-/-) cells. References: Cell Cycle. 2010 Feb 15; 9(4):761-73; Oncotarget. 2014 Apr 30; 5(8):2263-75. Related CAS: 775294-82-1 (free base)
Molecular Weight (MW)	479.4
Formula	C24H28Cl2N2O4
CAS No.	1052532-15-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 95 mg/mL (198.2 mM)
	Water:< 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3, 4-dimethoxyphenyl)ethanamine hydrochloride InChi Key: QBGSVDJLQQXEGG-UHFFFAOYSA-N InChi Code: InChI=1S/C24H27ClN2O4.ClH/c1-28-20-7-4-17(12-22(20)29-2)10-11-26-14-18-5-8-21(23(13-18)30-3)31-16-19-6-9-24(25)27-15-19; /h4-9, 12-13, 15, 26H, 10-11, 14, 16H2, 1-3H3; 1H SMILES Code: COC1=CC=C(CCNCC2=CC=C(OCC3=CC=C(Cl)N=C3)C(OC)=C2)C=C1OC.[H]Cl
Synonyms	SBE13 HCl; SBE 13; SBE13; SBE-13 HCl

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Amount: 10 mg

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Delivery expected until 9/4/2025

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