« Back
Home /
Epothilone A (Epo A)

Epothilone A (Epo A)

Item no.	V1619-500mg
Manufacturer	InvivoChem LLC
CASRN	152044-53-6
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1619CAS #:152044-53-6Purity >=98% Description: Epothilone A (also known as Epo A), similar to paclitaxel, is also a naturally occurring microtubule-stabilizing macrolide agent (also called mitotic inhibitor or tubulin inhibitor). It was first isolated from the myxobacterium Sorangium cellulosum. The IC50 value of Epothilone A in HCT-116 cell line is 4.4 nM. It has been found that the SKOV-3 human ovarian cancer cells were susceptible to Epothilone A with IC50 value of 20.4 +/- 1.4 nM. The antiproliferative capacity of Epothilone A in SKOV-3 cell line (measured as IC50 after 72 h continuous treatment) was six times greater than that of PTX’s. Besides, Epothilone A induced time coursedependent apoptosis and necrosis. References: Org Lett. 2001 Aug 23; 3(17):2693-6; Cancer Res. 1995 Jun 1; 55(11):2325-33.
Molecular Weight (MW)	493.66
Formula	C26H39NO6S
CAS No.	152044-53-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 99 mg/mL (200.5 mM)
	Water: < 1 mg/mL
	Ethanol: 99 mg/mL (200.5 mM)
SMILES	O=C(C(C)(C)[CH](O)C1)[CH](C)[CH](O)[CH](C)CCC[C]2([H])O[C]2([H])C[CH](/C(C)=C/C3=CSC(C)=N3)OC1=O
Synonyms	Epothilone-A; EpoA; (1R, 5S, 6S, 7R, 10S, 14S, 16S)-6, 10-Dihydroxy-5, 7, 9, 9-tetramethyl-14-[(E)-1-(2-methyl-1, 3-thiazol-4-yl)prop-1-en-2-yl]-13, 17-dioxabicyclo[14.1.0]heptadecane-8, 12-dione

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 500 mg

available

Delivery expected until 9/4/2025

Express Delivery: Save 6 days

Compare

Add to wishlist

Get an offer