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Padnarsertib (KPT-9274)

Padnarsertib (KPT-9274)

Item no.	V3144-250mg
Manufacturer	InvivoChem LLC
CASRN	1643913-93-2
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3144CAS #:1643913-93-2Purity >=98% Description: This product has been discontinued. KPT-9274 (PAK4-IN-1) is a potent, selective, orally bioavailable small molecule, non-competitive dual inhibitor of PAK4/NAMPT inhibitor. KPT-9274 disrupts the PAK4/NAMPT signaling pathway, which may lead to the reduction of G2-M transit and induction of apoptosis as well as decrease in cell invasion and migration in several human RCC cell lines. Inhibition of the PAK4 signaling pathway by KPT-9274 attenuates nuclear beta-catenin as well as the Wnt/beta-catenin targets cyclin D1 and c-Myc. KPT-9274 demonstrated the expected on-target effects in a mouse model and is under a phase I clinical trial for solid tumors and lymphomas. Description: References: Mol Cancer Ther. 2016 Sep; 15(9):2119-29. References:
Molecular Weight (MW)	610.63
Formula	C35H29F3N4O3
CAS No.	1643913-93-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (163.8 mM)
	Water: < 1 mg/mL
	Ethanol: 100 mg/mL (163.8 mM)
Chemical Name	(1Z, 2E)-3-(6-aminopyridin-2-yl)-N-((5-(4-(4, 4-difluoropiperidine-1-carbonyl)phenyl)-7-(4-fluorophenyl) benzofuran-2-yl)methyl)acrylimidic acid
Synonyms	KPT9274; KPT-9274; KPT 9274; PAK4-IN-1; PAK4-IN 1; PAK4-IN1
SMILES Code	OC(/C=C/C1=NC(N)=CC=C1)=N\CC2=CC3=CC(C4=CC=C(C(N5CCC(F)(F)CC5)=O)C=C4)=CC(C6=CC=C (F)C=C6)=C3O2

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 mg

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Delivery expected until 9/4/2025

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