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Description: Altretamine (also known as Hexamethylmelamine, NSC13875, ENT50852, WR-95704) is an alkylating anticancer drug which also acts as a chemosterilant for male houseflies and other insects. Altretamine was approved by the U.S. FDA in 1990. It is indicated for use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with cisplatin and/or alkylating agent-based combination. The precise mechanism by which altretamine exerts its anti-cancer effect is unknown but it is classified by MeSH as an alkylating antineoplastic agent.
References: Clin Pharmacokinet. 1995 Jun; 28(6):439-48.
Related CAS #: 2975-00-0 (HCl) 645-05-6 (free base)
Chemical Name: N2, N2, N4, N4, N6, N6-hexamethyl-1, 3, 5-triazine-2, 4, 6-triamine
InChi Key: UUVWYPNAQBNQJQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C9H18N6/c1-13(2)7-10-8(14(3)4)12-9(11-7)15(5)6/h1-6H3
SMILES Code: CN(C)C1=NC(N(C)C)=NC(N(C)C)=N1
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