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Description: GBR-12935 is a novel, potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. This has led to potential clinical uses in the diagnosis of Parkinson's disease, although selective radioligands such as Ioflupane are now available for this application. GBR-12935 is now widely used in animal research into Parkinson's disease and the dopamine pathways in the brain.
References: Eur J Pharmacol. 2001 Feb 23; 414(1):37-44.; Biochem Pharmacol. 1997 Jun 15; 53(12):1937-9.
Related CAS#: 67469-81-2 (HCl); 76778-22-8 (free base)
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