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febuxostat

febuxostat

Item no.	V2072-10g
Manufacturer	InvivoChem LLC
CASRN	144060-53-7
Amount	10 g
Quantity options	100 mg 1 g 250 mg 500 mg 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2072CAS #:144060-53-7 Purity >=98% Description: Febuxostat (formerly also called TMX 67, TEI-6720; TEI 6720; Uloric; TMX-67) is a potent and selective xanthine oxidase inhibitor with Ki of 0.6 nM and has been used to treat hyperuricemia and chronic gout. Febuxostat displayed potent mixed-type inhibition of the activity of xanthine oxidase (XO). Febuxostat was also reported to be 1000-fold (IC50=1.8 nM) more potent than allopurinol (IC50= 2.9 uM) at inhibiting XO-dependent uric acid formation. In a previous study, the authors investigated the effects of febuxostat on several enzymes in purine and pyrimidine metabolism and characterized the mechanism of febuxostat inhibition of XO activity. Results showed that Febuxostat displayed potent mixed-type inhibition of the activity of purified bovine milk XO, indicating inhibition of both the oxidized and reduced forms of XO. References: Life Sci. 2005 Mar 4; 76(16):1835-47. Epub 2005 Jan 18; Am J Physiol Renal Physiol. 2008 Apr; 294(4):F710-8; Nephron Physiol. 2008; 108(4):p69-78. Related CAS#: 1246819-50-0 (Febuxostat D9 is deuterium labeled Febuxostat)
Molecular Weight (MW)	316.37
Formula	C16H16N2O3S
CAS No.	144060-53-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 63 mg/mL (199.1 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	Chemical Name: 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid InChi Key: BQSJTQLCZDPROO-UHFFFAOYSA-N InChi Code: InChI=1S/C16H16N2O3S/c1-9(2)8-21-13-5-4-11(6-12(13)7-17)15-18-10(3)14(22-15)16(19)20/h4-6, 9H, 8H2, 1-3H3, (H, 19, 20) SMILES Code: O=C(C1=C(C)N=C(C2=CC=C(OCC(C)C)C(C#N)=C2)S1)O
Synonyms	TMX 67, TEI-6720; TMX-67; TEI-6720; TEI 6720; TMX67; TEI6720; Uloric; Adenuric

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 g

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Delivery expected until 9/4/2025

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