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Omapatrilat (BMS-186716)

Omapatrilat (BMS-186716)

Item no.	V2076-10mg
Manufacturer	InvivoChem LLC
CASRN	167305-00-2
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2076CAS #:167305-00-2Purity >=98% Description: Omapatrilat (also known as BMS-186716) is a novel antihypertensive agent that acts as a potent dual inhibitor of the metalloproteases ACE (angiotensin converting enzyme) and NEP (neutral endopeptidase) with Ki values of 0.64 and 0.45 nM, respectively. Omapatrilat has antihypertensive activity. NEP inhibition results in elevated natriuretic peptide levels, promoting natriuresis, diuresis, vasodilation, and reductions in preload and ventricular remodeling. The drug was promoted for possible uses in congestive heart failure. References: J Med Chem. 1997 May 23; 40(11):1570-7.; Br J Pharmacol. 2008 Mar; 153(5):947-55.
	Name: Omapatrilat CAS#: 167305-00-2 Chemical Formula: C19H24N2O4S2 Exact Mass: 408.1177 Molecular Weight: 408.5349 Elemental Analysis: C, 55.86; H, 5.92; N, 6.86; O, 15.67; S, 15.70
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: BMS 186716; BMS-186716; BMS186716; Vanlev Chemical Name: (4S, 7S, 10aS)-4-((S)-2-mercapto-3-phenylpropanamido)-5-oxooctahydro-2H-pyrido[2, 1-b][1, 3]thiazepine-7-carboxylic acid InChi Key: LVRLSYPNFFBYCZ-VGWMRTNUSA-N InChi Code: InChI=1S/C19H24N2O4S2/c22-17(15(26)11-12-5-2-1-3-6-12)20-13-9-10-27-16-8-4-7-14(19(24)25)21(16)18(13)23/h1-3, 5-6, 13-16, 26H, 4, 7-11H2, (H, 20, 22)(H, 24, 25)/t13-, 14-, 15-, 16-/m0/s1 SMILES Code: O=C([CH]1CCC[C](N21)([H])SCC[CH](NC([CH](S)CC3=CC=CC=C3)=O)C2=O)O

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Amount: 10 mg

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Delivery expected until 12/4/2025

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