jtz-951-hcl

Description: Enarodustat HCl (JTZ-951) is an antianaemic drug candidate that acts as a potent and orally active factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 uM. Enarodustat has the potential for renal anemia treatment. JTZ-951 (enarodustat) stabilizes HIF-alpha protein and induces erythropoiesis without effects on the function of vascular endothelial growth factor. Enarodustat increases endogenous erythropoietin levels in the treatment of anemia associated with chronic kidney disease (CKD). JTZ-951 induces erythropoiesis without affecting VEGF function. JTZ-951 may be a new oral candidate that increases and maintains hemoglobin concentrations in renal anemia patients.

References: Ogoshi Y, et al. Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia. ACS Med Chem Lett. 2017 Nov 20; 8(12):1320-1325.