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Description: Olsalazine Sodium (CJ-91B) is a potent anti-inflammatory prodrug, which consists of two 5-ASA moieties linked by an azo bond.Olsalazine displays multiple effects on intestinal electrolyte. In vitro application of Olsalazine (< 2.89 mM) increases the secretion of both sodium and chloride ions and decreases chloride ion absorption in rat and rabbit ileal mucosa. Concentration of Olsalazine < 11.5 mM also dose-dependently decreases net sodium and, to a greater degree, chloride absorption in the isolated rat colon. Potassium secretion is also increases but only at a high Olsalazine concentration (11.5 mM).
References: Drugs. 1991 Apr; 41(4):647-64.
Related CAS #: 15722-48-2 (free acid) 6054-98-4 (sodium)
Chemical Name: sodium (E)-5, 5'-(diazene-1, 2-diyl)bis(2-hydroxybenzoate)
InChi Key: ZJEFYLVGGFISGT-VRZXRVJBSA-L
InChi Code: InChI=1S/C14H10N2O6.2Na/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22; ; /h1-6, 17-18H, (H, 19, 20)(H, 21, 22); ; /q; 2*+1/p-2/b16-15+; ;
SMILES Code: O=C([O-])C1=C(O)C=CC(/N=N/C2=CC(C([O-])=O)=C(O)C=C2)=C1.[Na+].[Na+]
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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